A functional assay for mutations in tumor suppressor genes caused by mismatch repair deficiency
نویسندگان
چکیده
منابع مشابه
A functional assay for mutations in tumor suppressor genes caused by mismatch repair deficiency.
The coding sequences of multiple human tumor suppressor genes include microsatellite sequences that are prone to mutations. Saccharomyces cerevisiae strains deficient in DNA mismatch repair (MMR) can be used to determine de novo mutation rates of these human tumor suppressor genes as well as any other gene sequence. Microsatellites in human TGFBR2, PTEN and APC genes were placed in yeast vector...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2001
ISSN: 1460-2083
DOI: 10.1093/hmg/10.24.2737